HA oral supplementation as a gel for animals and/or a slow dissolving lozenge for humans takes advantage of CD44 receptors in the oral cavity to promote absorption to the vascularized mucosa thus by passing stomach acidity and intestinal enzyme destruction.
High molecular weight HA, a biopolymer, has been shown in published research studies to:
maintain cellular structure and function
enhance processes of cell signaling, wound repair/regeneration, and extracellular matrix organization
Specifically HA has been shown to:
effect joint function and decrease pain associated with osteoarthritis
maintain healthy skin via collagen regeneration and proliferation of skin fibroblasts within the collagen matrix
protect human corneal epithelial cells against UVB - induced apoptosis and reduced UVB-induced release of pro-inflammatory mediators via interaction of HA with corneal cell CD44 receptors.
relieve dry eye discomfort with oral HA supplementation
Improve plaque-induced gingivitis through its anti-inflammatory and antibacterial effects
demonstrate improvement in several dental hygiene health problems, including
post-tooth extraction healing times
xerostomia (dry mouth) by improving salivation
reducing C-reactive protein levels (total inflammatory burden of the body) by improving overall health of the mouth and gums and decreasing significantly cardiac disease due to oral disease processes
Conclusion: HA beneficial actions are mediated by HA-specific affinity to the oral mucosa and CD44 receptors that are associated with endothelial, epithelial and smooth muscle cell membranes. Oral HA supplementation via slow-release gel or lozenge forms provides an ideal way to enhance bioavailability important in joint protection, maintenance of healthy eyes, skin tissues, and protection from oral disease.